We are committed to developing safe and effective therapies and providing those therapies to the broadest group of patients as quickly as possible. If any signs of infection or meningitis occur, contact your child’s doctor immediately. BioMarin Pharmaceutical Inc. is a biotechnology company. If anaphylaxis occurs, immediately discontinue infusion and initiate appropriate medical treatment. Your child’s doctor should inspect the scalp and collect samples of your child’s cerebrospinal fluid (CSF) prior to each infusion of Brineura, to check that there is no device failure or infections present. Our thoughtful approach to clinical trial design enables us to move fast and efficiently while protecting the safety of our patients. Safety and effectiveness in pediatric patients below 3 years of age have not been established. These are not all of the possible side effects with Brineura. BioMarin Pharmaceutical Inc. 770 Lindaro Street San Rafael, CA 94901 At BioMarin, we focus on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. PALYNZIQ® (pegvaliase-pqpz) Injection for PKU; Kuvan® (sapropterin dihydrochloride) for PKU; Brineura® (cerliponase alfa) for CLN2 Disease; ALDURAZYME® (laronidase) for MPS I; … CLN2 disease is an ultra-rare and rapidly progressing brain disorder that affects an estimated 20 children born in the United States each year–less than one in a million Americans. This BioMarin process requires an in person interview at one of our company locations and never requires payment or fees from job applicants. For more information, please see our, Valoctocogene Roxaparvovec for Severe Hemophilia A, PALYNZIQ® (pegvaliase-pqpz) Injection for PKU, Kuvan® (sapropterin dihydrochloride) for PKU, Vimizim® (elosulfase alfa) for Morquio A Syndrome (MPS IVA). Low blood pressure and/or slow heart rate may occur during and following the Brineura infusion. BioMarin Pharmaceutical Inc 307 12th Ave Indian Rocks Beach FL 33785. Biomarin Pharmaceutical Inc ... With six highly innovative products developed, approved and commercialized for a variety of rare conditions over the last two decades, this is familiar … If a severe reaction occurs, the infusion will be stopped and your child will receive appropriate medical treatment. BioMarin Pharmaceutical Inc. has collaboration and license agreements with Sarepta Therapeutics and Asubio Pharma Company; and a preclinical collaboration and license agreement with DiNAQOR AG … Traci McCarty - VP, IR. BioMarin Pharmaceutical Inc. is a biotechnology company. Call your doctor for medical advice about side effects. Reviews (415) 506-6700 Website. SAN RAFAEL, Calif., Jan. 10, 2021 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) today announced positive topline results from its ongoing global Phase 3 GENEr8 … The most common side effects reported during Brineura infusions included fever, problems with the electrical activity of the heart, decreased or increased protein in the fluid of the brain, vomiting, seizures, hypersensitivity, collection of blood outside of blood vessels (hematoma), headache, irritability, and increased white blood cell count in the fluid of the brain, device-related infection, slow heart rate, feeling jittery, and low blood pressure. BioMarin sells multiple drugs for rare diseases, but valrox is its first legitimate chance to have a blockbuster treatment with more than $1 billion in sales. As of December 31, 2016, the … In the event you receive a suspicious email message about recruiting on behalf of BioMarin… As of 2016, BioMarin has six products on the market, each of which is an orphan drug. Brineura should not be used in patients with active intraventricular access device-related complications (e.g., leakage, device failure, or device-related infection, including meningitis), symptom of acute, unresolved localized infection around the device insertion site (e.g. BioMarin Pharmaceutical Inc. (BMRN Quick Quote BMRN - Free Report) BioMarin announced one-year follow-up data from a phase III study on its pipeline candidate, valoctocogene … SAN RAFAEL, Calif., Dec. 21, 2020 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) today announced that children in the open-label long-term extension of the Phase … If any signs of anaphylaxis occur, immediately seek medical care. Brineura® (cerliponase alfa) is indicated to slow the loss of ambulation in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase 1 (TPP1) deficiency. Brineura® (cerliponase alfa) is a prescription medication used to slow loss of ability to walk or crawl (ambulation) in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase 1 (TPP1) deficiency. Your doctor should vigilantly be looking for signs and symptoms of infection, including meningitis, during treatment with Brineura. Our Products. Jean-Jacques Bienaimé - Chairman and … BioMarin Pharmaceutical Inc BioMarin Pharmaceutical Inc. develops and commercializes therapeutic enzyme products. cellulitis or abscess), or and with shunts used to drain extra fluid around the brain. Biomarin Pharmaceutical Inc ... commercial products and potential future products in different areas of therapeutic research and development. Each drug candidate we pursue is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. Talk to your child’s doctor if they have any symptoms that bother them or that do not go away. Tell the doctor if they are sick or taking any medication and if they are allergic to any medicines. Before treatment with Brineura, it is important to discuss your child’s medical history with their doctor. Each drug candidate we pursue is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. Undesirable or hypersensitivity reactions related to Brineura treatment, including fever, vomiting, and irritability, may occur during treatment and as late as 24 hours after infusion. PALYNZIQ ® (pegvaliase-pqpz) Injection for PKU; Brineura ® (cerliponase alfa) for CLN2 Disease; Vimizim ® (elosulfase alfa) for Morquio A Syndrome (MPS IVA); Kuvan ® (sapropterin … For more information, please see our, Valoctocogene Roxaparvovec for Severe Hemophilia A, PALYNZIQ® (pegvaliase-pqpz) Injection for PKU, Kuvan® (sapropterin dihydrochloride) for PKU, Brineura® (cerliponase alfa) for CLN2 Disease, Vimizim® (elosulfase alfa) for Morquio A Syndrome (MPS IVA), BioMarin Announces Positive Phase 3 Gene Therapy Trial Results in Adults with Severe Hemophilia A; Study Met All Primary and Secondary Efficacy Endpoints in One-Year Data Set, BioMarin to Participate in Two Upcoming Virtual Investor Conferences, BioMarin Announces Benefit Maintained for Over Two Years in Children with Achondroplasia Treated with Vosoritide in Phase 3 Extension Study, BioMarin and Deep Genomics to Collaborate on Advancing Programs Identified Using Artificial Intelligence, BioMarin to Participate in Three Upcoming Virtual Investor Conferences, BioMarin Expands Vosoritide Clinical Program, BioMarin Announces Third Quarter 2020 Total Revenues of $477 Million. Phase (Preclinical, Phase 1, Phase 2, Phase 3, BLA/NDA/MAA, Approval), Brineura® (cerliponase alfa) for CLN2 Disease, This website uses cookies to improve website functionality. Please see accompanying full Prescribing Information, or visit www.Brineura.com. The Company has applied its proprietary enzyme technology to develop products for lysosomal storage … Brineura is only given by infusion into the fluid of the brain (known as an intraventricular injection) and using sterile technique to reduce the risk of infection. You may report side effects to BioMarin Pharmaceutical Inc. at 1-866-906-6100, or the FDA at 1-800-FDA-1088 or go to www.fda.gov/medwatch. Please note that any opinions, estimates or forecasts regarding BioMarin Pharmaceutical Inc.'s performance made by these analysts are theirs alone and do not represent opinions, forecasts or predictions of BioMarin Pharmaceutical Inc. or its management. Intraventricular access device-related infections, including meningitis, were observed with Brineura treatment. Your child may receive medication such as antihistamines before Brineura infusions to reduce the risk of reactions. BioMarin Pharmaceutical Inc. (NASDAQ:BMRN) Q3 2020 Earnings Conference Call November 5, 2020 4:30 PM ET Company Participants. If a reaction occurs, the infusion will be stopped and your child may be given additional medication. The signs and symptoms of infections may not be readily apparent in patients with CLN2 disease. The Company develops and commercializes pharmaceuticals for various diseases and medical conditions. Your child’s doctor will decide if Brineura is right for them. Brineura is the first enzyme replacement therapy to be directly administered into the fluid of the brain, treating the underlying cause of CLN2 disease by helping to replace the deficient TPP1 enzyme missing in affected children. Get directions, reviews and information for BioMarin Pharmaceutical Inc in Indian Rocks Beach, FL. BioMarin Pharmaceutical Inc’s price can fluctuate throughout the course of each trading day—when you buy BioMarin Pharmaceutical Inc through Stash, we execute the market order during our next … Our Products. We are committed to the communities we treat beyond the therapies we develop. ... Its commercial products … Your child’s intraventricular access device should be replaced prior to 4 years of single-puncture administration of Brineura, because the device may deteriorate due to repeated use. PALYNZIQ ® (pegvaliase-pqpz) Injection for PKU; Brineura ® (cerliponase alfa) for CLN2 Disease; Vimizim ® (elosulfase alfa) for Morquio A Syndrome (MPS IVA) Kuvan ® (sapropterin … Biomarin Pharmaceutical Inc (NASDAQ:BMRN) Q2 2020 Earnings Call Aug 4, 2020, 4:30 p.m. The Company has applied its proprietary enzyme technology to develop products … Intraventricular device-related side effects included infection, delivery system-related complications, and increased white blood cell count in fluid of the brain. Due to the potential for anaphylaxis, appropriate medical support should be readily available, and patients should be observed closely, during and after Brineura infusion. If you have questions or would like more information about Brineura, contact your child’s doctor. Results may differ materially depending on … BioMarin Pharmaceutical Inc. 770 Lindaro Street San Rafael, CA 94901 Directions › Tel: +1 (415) 506-6700 E-mail: Media Relations E-mail: Investor Relations *Please direct all mail to the U.S. mailing … BioMarin Pharmaceutical Inc. The company's Vimizim, Naglazyme, and Aldurazyme drugs treat versions of the life-threatening genetic condition … You may delete or block cookies by accessing your preferences. Contents: Prepared Remarks; Questions and Answers; Call Participants; Prepared … Contact your child’s doctor immediately if these reactions occur. The Company develops and commercializes pharmaceuticals for various diseases and medical conditions. ... Pharmaceutical Products Wholesale Pharmaceutical Products … Serious and severe allergic reactions (anaphylaxis) may occur. You may delete or block cookies by accessing your preferences. Our Products. BioMarin Pharmaceutical, Inc. is a biotechnology company, which engages in the development and commercialization of therapies for people with serious and life-threatening rare … Inform patients/caregivers of the signs and symptoms of anaphylaxis and to seek immediate medical care should these occur. BioMarin Pharmaceuticals develops drugs with a focus on rare disease treatments. Brineura is a prescription medicine. BioMarin Pharmaceutical Inc. Biotechnology San Rafael, CA 83,874 followers We bring new treatments to market that will make a big impact on small patient populations. ET. BioMarin … BioMarin Pharmaceutical Inc. develops and commercializes therapeutic enzyme products. PALYNZIQ ® (pegvaliase-pqpz) Injection; Brineura ® (cerliponase alfa) Vimizim ® (elosulfase alfa) Kuvan ® (sapropterin dihydrochloride) Naglazyme ® (galsulfase) Aldurazyme ® … Our Products. An intraventricular access device or port must be in place at least 5 to 7 days prior to the first infusion. Consider the risks and benefits of readministration of Brineura following an anaphylactic reaction. This website uses cookies to improve website functionality. BioMarin Pharmaceutical Inc… Details BioMarin is a global pharmaceutical company focused on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients … Vigilantly be looking for signs and symptoms of infections may not be readily apparent in patients CLN2... Any medication and if they are sick or taking any medication and biomarin pharmaceutical inc products they have symptoms! Quickly as possible be given additional medication, contact your child’s doctor immediately if these occur... Delivery system-related complications, and Aldurazyme drugs treat versions of the condition it will address Brineura is for... If anaphylaxis occurs, immediately discontinue infusion and initiate appropriate medical treatment by a fundamental understanding of the condition will! 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