Neither this announcement nor anything contained herein shall form the basis of, or be relied upon in connection with, any offer or commitment whatsoever in any jurisdiction. Foralumab is the only fully human anti-CD3 monoclonal antibody (mAb) in clinical development in the world. These statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties, and other factors, some of which are beyond the Company’s control, are difficult to predict, and could cause actual results to differ materially from those expressed or forecasted in the forward-looking statements. The company is accelerating development of anti-Interleukin 6 receptor (IL6R) mAb, a fully human monoclonal antibody for treatment of IL6-induced inflammation, especially for treatment of COVID-19 patients with severe respiratory symptoms.This announcement contains inside information for the purposes of Article 7 of EU Regulation 596/2014. Additionally, the Company earlier reported data from an animal study suggesting that the combination of Milciclib with Sorafenib, both acting via different mechanisms, suppressed expression of protooncogene c-Myc to produce pronounced synergistic anti-HCC activity(3). Latest Share Price and Events. The company is accelerating development of anti-Interleukin 6 receptor (IL6R) mAb, a fully human monoclonal antibody for treatment of IL6-induced inflammation, especially for treatment of COVID-19 patients.Forward-Looking Statements Certain statements made in this announcement are forward-looking statements. TILS Share Price Performance. CDKs are serine threonine kinases that play crucial roles in progression of the cell cycle from G1 to S phase. 55 Park LaneLondon W1K 1NAUnited Kingdom44 20 7495 2379http://www.tizianalifesciences.com, Sector(s): HealthcareIndustry: BiotechnologyFull Time Employees: 8. Accordingly, no Accustem Shares will be actually issued (or CREST accounts credited or Accustem ADSs issued) until the earlier of (i) Accustem Admission; and (ii) 2 months from the date of the completion of the Demerger. NEW YORK and LONDON, Aug. 24, 2020 (GLOBE NEWSWIRE) -- Tiziana Life Sciences plc (Nasdaq: TLSA; AIM: TILS) (“Tiziana” or the “Company”), a biotechnology company focused on innovative therapeutics for oncology, inflammation and infectious diseases, announces that the United States Patent and Trademark Office (“USPTO”) has granted a patent for methods and use of fully human monoclonal antibody (mAb; TZLS-501) that recognizes both IL-6 receptor (IL-6R) and IL-6 receptor complex with IL-6 (IL-6R/IL-6) for prophylactic and therapeutic intervention for human diseases. Foralumab is the only fully human anti-CD3 monoclonal antibody in clinical development in the world. It is not uncommon to see companies perform well in the years after insiders buy shares. About Tiziana Life Sciences Tiziana Life Sciences plc is a dual listed (NASDAQ: TLSA & UK AIM: TILS) biotechnology company that focuses on the discovery and development of novel molecules to treat human diseases in oncology, inflammation and infectious diseases. This phase II compound has potential application in a wide range of autoimmune and inflammatory diseases, such as Crohn’s Disease, multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. The cytokine, IL-6, a major determinant in the priming of pathogenic T cells to produce an inflammatory response, binds to its receptor subunit IL-6Rα on the cell membrane. This page provides a graphical presentation of Telstra's share price details (both TLS and TLSCA) from 1999 to the present. “Brazil has reported almost 5.5M Coronavius cases and 159,000 deaths and is considered a global epicenter of the outbreak. doi:10.1172/JCI137244About Foralumab Foralumab (formerly NI-0401), the only entirely human anti-CD3 mAb, shows reduced release of cytokines after IV administration in patients with Crohn's disease with decreases in the classic side effects of cytokine release syndrome (CRS) and improves the overall safety profile of Foralumab. Chen G, Wu D, Guo W, et al. The downstream signaling from which sIL-6R is implicated mediates pro-inflammatory effect underlying the inflammatory diseases such as rheumatoid arthritis (RA) and acute respiratory distress syndrome (ARDS). (See TLSA stock analysis on TipRanks).Related News: Pfizer Inks Deal To Manufacture Gilead’s Covid-19 Remdesivir Treatment Krystal’s ‘Promising’ Cystic Fibrosis Drug Scores Orphan Designation Gilead ‘Very Pleased’ With Tango Collab, Boosts Cancer Targets To 15 More recent articles from Smarter Analyst: * American Express To Acquire Online Lender Kabbage * Susquehanna Lifts Nvidia’s PT To ‘Street High’ Ahead of Tomorrow's 2Q Results * Home Depot Sales Exceed Estimates As Shoppers Pile On DIY Products * Hilton vs Marriott: Which Hotel Stock Is Best Poised For Recovery? If it isn't grown, it has to be mined. Since then, TILS stock has increased by 1.2% and is now trading at GBX 86.05. Tiziana Life Sciences January 9, 2020 Press Release (https://ir.tizianalifesciences.com/news-releases/news-release-details/tiziana-life-sci-plc-further-re-foralumab-phase-1-trial)3\. These forward-looking statements are not historical facts but rather are based on the Company’s current expectations, estimates, and projections about its industry; its beliefs; and assumptions. Results from studies, conducted in our laboratory have established that nasal administration of anti-CD3 induces Tregs that can suppress inflammation and ameliorate diseases in animal models. Price. The Company will not undertake any obligation to release publicly any revisions or updates to these forward-looking statements to reflect events, circumstances, or unanticipated events occurring after the date of this announcement except as required by law or by any appropriate regulatory authority.For further enquiries:United Kingdom:Tiziana Life Sciences plc Gabriele Cerrone, Chairman and founder +44 (0)20 7495 2379Cairn Financial Advisers LLP (Nominated adviser) Liam Murray / Jo Turner +44 (0)20 7213 0880 Optiva Securities Limited (Broker) Robert Emmet +44 (0)20 3981 4173United States:Investors Dave Gentry, CEO RedChip Companies Inc. 407-491-4498 dave@redchip.com, Proposed capital reduction and notice of General MeetingLONDON, Sept. 16, 2020 (GLOBE NEWSWIRE) -- Tiziana Life Sciences Plc (LSE: TILS, NASDAQ: TLSA) a biotechnology company focussed on innovative therapeutics for oncology, inflammation and infectious diseases, today announces that, following a strategic review of its clinical trial programs and core focus, it intends to demerge its StemPrintER and SPARE genomics-based personalised medicine business into a separate and independent listed company, Accustem Sciences Limited. View dividend history, insider trades and ASX analyst consensus. Huang C, Wang Y, Li X, et al. NEW YORK and LONDON, Aug. 20, 2020 (GLOBE NEWSWIRE) -- Tiziana Life Sciences plc (Nasdaq: TLSA; AIM: TILS) (“Tiziana” or the “Company”), a biotechnology company focused on innovative therapeutics for oncology, inflammation and infectious diseases, announces that Dr. Napoleone Ferrara, MD, Professor at the University of California San Diego Medical Center, has agreed to serve on its scientific advisory board (SAB) for an additional three year term. Use of Milciclib in combination with a Tyrosine Kinase Inhibitor such as Sorafenib or Regorafenib for treatment of hepatocellular carcinoma and other cancersDr. High / Low. Today, the TLS share price has continued its upward trajectory, pushing shares within arm’s reach of its pre-COVID level. TIL Ltd share price live updates on The Economic Times. The interview will air Sunday, 27 September 2020, at 6 p.m. EST on Bloomberg International, available in 100+ million homes across Europe. Grand View Research August 2018 (https://www.grandviewresearch.com/press-release/global-crohns-disease-therapeutics-market).2\. In addition to milciclib, the Company will be shortly initiating phase 2 studies with orally administered foralumab for Crohn’s Disease and nasally administered foralumab for progressive multiple sclerosis. Dr. Ferrara is a member of The National Academy of Sciences and has received numerous prestigious awards, including the Lasker Award and the Breakthrough Prize in Life Sciences. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. However, severe toxicities and poor patient compliance limit the long-term use for intravenous immunotherapies. Clinical and immunological features of severe and moderate coronavirus disease 2019. ET) and the After Hours Market (4:00-8:00 p.m. Pivetti, A., Di Marco, L., Bristot, L., Milosa, F., Maria Critelli, R., De Maria, N., Di Benedetto, F., Palejwala, V., Jacob, J., Shailubhai, K., and Villa, E. (2020) Safety and Clinical Activity of Combination Treatment with Regorafenib and Milciclib in Liver Transplant Patients with Hepatocellular Carcinoma Recurrence. Sell. The scientific concept, to activate nasal mucosal immunity by nasally administered Foralumab, is to fight against the virus in the respiratory tract and lungs,” stated Dr. Shailubhai, CEO and CSO of Tiziana Life Sciences. Find the latest TELSTRA FPO (TLS.AX) stock quote, history, news and other vital information to help you with your stock trading and investing. This scientific advancement provides the basis to move forward with clinical development of nasally administered Foralumab in COVID-19 disease,” commented Dr. Howard Weiner, who is the Robert L. Kroc Professor of Neurology at the Harvard Medical School, Director and Founder of the Partners Multiple Sclerosis Center and Co-Director of the Ann Romney Center for Neurologic Diseases at the Brigham & Women’s Hospital. Dr. Ferrara also discovered that VEGF is a key mediator of angiogenesis associated with intraocular neovascular syndromes. Subsequently, we plan to use TZLS-501 with the same inhalation delivery technology for the treatment of patients with ARDS”, added Dr. Kunwar Shailubhai, CEO & CSO of Tiziana.The person who arranged for the release of this announcement on behalf of the Company was Dr Kunwar Shailubhai, CEO & CSO of Tiziana.About TZLS-501 TZLS-501, a fully human mAb, was acquired from Novimmune, SA, a Swiss biotechnology company, in 2017. Many studies have also indicated excessive levels of IL-6 in the lungs and in the blood of these patients, and it is believed that the cytokine storm in lungs is primarily due to excessive levels of IL-6.As a result, direct inhalation delivery of TZLS-501 to the lungs has the potential to deplete circulating levels of IL-6 and inhibit IL-6R signaling, providing immediate relief to COVID-19 patients, says the company.Year-to-date the stock has rallied an incredible 260%- and HC Wainwright analyst Ram Selvaraju is bullish on Tiziana’s outlook. The approaches to administer mAbs by oral and nasal routes to stimulate mucosal immune system to induce disease modifying benefits are like human physiological defense systems. Tiziana Life Sciences PLC (TILS:LSE) forecasts: consensus recommendations, research reports, share price forecasts, dividends, and earning history and estimates. Earnings Announcement for Period Ending Y/2020. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. This phase II compound has potential application in a wide range of autoimmune and inflammatory diseases, such as Crohn’s Disease, multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. The clinical data from this trial is expected to available by the end of this year. The person who arranged the release of this information is Keeren Shah, Finance Director of Tiziana.For further enquiries:United Kingdom Investors:Tiziana Life Sciences plc Gabriele Cerrone, Chairman and founder +44 (0)20 7495 2379 Cairn Financial Advisers LLP (Nominated Adviser) Liam Murray / Jo Turner +44 (0)20 7213 0880 Optiva Securities Limited (Broker) Robert Emmet \+ 44 (0)20 3981 4173 United States Investors:Dave Gentry RedChip Companies Inc. Office 1 800 RED CHIP (733 2447) Cell 407-491-4498 (USA) dave@redchip.com. When the traded price is any other currency then the Trade Value is displayed in that currency. 10,759,858.Shares in the biotech are now spiking 25% in Tuesday’s pre-market trading.Recently, Tiziana also announced the issuance of the first-ever patent on oral administration of anti-CD3 mAbs for treatment of human diseases.TLSA previously reported the successful completion of a Phase 1 trial utilizing oral administration of Foralumab on 9 January, 2020, which was designed to evaluate its safety and tolerability in healthy subjects.It now plans to move forward with a phase 2 trial in the 4th quarter of 2020 with orally administered Foralumab for the evaluation of moderate-to-severe patients with Crohn’s Disease.Dr. The second poster was on the evaluation of Milciclib in combination with Regorafenib, a specific TKI drug, in liver transplant patients with HCC recurrence in the MiHRCO (Milciclib and Half Regorafenib CO administration) trial. This Phase 2 compound has potential application in a wide range of autoimmune and inflammatory diseases, such as Crohn’s Disease, multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. In a phase I study, oral treatment with Milciclib was found to be well-tolerated and the drug showed promising clinical responses in patients with advanced solid malignancies such as in NSCLC, pancreatic and colon cancer, thymic carcinoma and thymoma. CD is a chronic disorder of the immune system that causes inflammation throughout the digestive tract. Find out how to deal online from £1.50 in a SIPP, ISA or Dealing account. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. Since the reduction in Tregs and activation of the immune system are commonly observed in patients with Middle Eastern Middle Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS-CoV-1), COVID-19 and Acute Respiratory Distress Syndrome (ARDS), we believe that stimulation of Tregs is a highly innovative approach for the treatment of patients with these diseases.The Company has developed a robust formulation for delivery of Foralumab using a nasal spray device and has successfully completed a Phase 1 clinical trial demonstrating that the treatment was well-tolerated up to 250 microg/day and that it stimulated Tregs (https://www.tizianalifesciences.com/news-item?s=2018-11-28-tiziana-announces-initiation-of-phase-1-clinical-trial-with-nasal-administration-of-foralumab-a-fully-human-anti-cluster-definition-3-monoclonal-antibody-anti-cd3-mab-in-healthy-volunteers). Clin Dev Immunol 2012, 4250214\. Dr. Kunwar Shailubhai, CEO & CSO of Tiziana Lifesciences, commented, “Advanced cases of patients with HCC have limited therapeutic options because of the heterogeneity of the multiple mechanisms underlying the development of drug resistance and limited clinical responses. Please upgrade the browser to the latest. Furthermore, nasal anti-CD3 dampens cytotoxic CD8 T cell responses shown to cause lung damage in COVID-19. Ranibizumab and other anti-VEGF agents have had a dramatic impact on the development of therapies for these blinding disorders.Dr. This additional patent on TZLS-501 is significant for the potential treatment of COVID-19 and other pulmonary diseases such as acute respiratory distress syndrome (ARDS), TLSA stated.“We are expediting the clinical development of TZLS-501, GMP manufacturing, simultaneously developing inhalation delivery directly to the lungs using a nebulizer and conducting the inhalation safety toxicology studies in Cynomolgus monkeys” commented Dr. Kunwar Shailubhai, CEO & CSO of Tiziana.“Completion of these studies will enable us to file an IND and initiate a clinical trial in COVID-19 patients by Q1 2021. Results from studies, conducted in our laboratory have established that nasal administration of anti-CD3 induces Tregs that can suppress inflammation and ameliorate diseases in animal models. Open / Last close. Napoleone Ferrara stated: “I am excited to continue to serve on Tiziana’s SAB as I believe that the immunotherapy pipeline of the company is highly innovative and conceptually very logical. Toll-Free) or +1-201-389-0878 (International) Webcast:http://public.viavid.com/index.php?id=142634 For interested individuals unable to join the conference call, a dial-in replay of the call will be available until 16 December 2020 and can be accessed by dialing +1-844-512-2921 (U.S. Toll Free) or +1-412-317-6671 (International) and entering replay pin number: 13713850.About Tiziana Life SciencesTiziana Life Sciences plc is a UK biotechnology company that focuses on the discovery and development of novel molecules to treat human disease in oncology and immunology. Completion of these studies will enable us to file an IND and initiate a clinical trial in COVID-19 patients by Q1 2021. In a humanized mouse model (NOD/SCID IL2γc-/-), it was shown that whilst targeting the T cell receptor, orally administered Foralumab modulates immune responses of the T cells, enhances regulatory T-cells (Tregs) and thus provides therapeutic benefit in treating inflammatory and autoimmune diseases without the occurrence of potential adverse events usually associated with parenteral mAb therapy (Ogura M. et al., 2017). * Clinical study anticipated to start in the next few weeks with clinical data potentially available before the end of 2020 * Scientific rationale for use of Foralumab as a treatment for COVID-19 patients is to help modulate the human immune system to suppress a possible “Cytokine storm” and to potentially reduce respiratory failure in COVID-19 patientsThe “Cytokine storm” (aka cytokine release syndrome) and hyperinflammation resulting in severe lung damage, followed by respiratory failure are the main underlying reasons for morbidity and mortality in COVID-19 patients (1). In a side-by-side comparison study, StemPrintER was 40% more accurate than the Oncotype DX assay. ET). This action will not suspend Nasdaq trading of the Tiziana ADSs. The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements, which reflect the view of the Company only as of the date of this announcement. The Company will not undertake any obligation to release publicly any revisions or updates to these forward-looking statements to reflect events, circumstances, or unanticipated events occurring after the date of this announcement except as required by law or by any appropriate regulatory authority.For further enquiries:United Kingdom Investors:Tiziana Life Sciences plc Gabriele Cerrone, Chairman and founder +44 (0)20 7495 2379 Cairn Financial Advisers LLP (Nominated Adviser) Liam Murray / Jo Turner +44 (0)20 7213 0880 Optiva Securities Limited (Broker) Robert Emmet \+ 44 (0)20 3981 4173 United States Investors:Dave Gentry RedChip Companies Inc. Office 1 800 RED CHIP (733 2447) Cell 407-491-4498 (USA) dave@redchip.com. Chat About TILS Shares - Stock Quote, Charts, Trade History, Share Chat, Financial Terms Glossary. In return for this transfer, Accustem will allot Accustem Shares to Tiziana Shareholders who are registered on the Tiziana Share Register at the Demerger Record Time, on the basis of one Accustem Share for each Tiziana Share held by them at that time, save that the number of Accustem Shares to be allotted to the initial subscriber in Accustem (who is, and will at the Demerger Record Time continue to be, a Tiziana Shareholder) will be reduced by the number of Accustem Shares already held by them so that, upon the Demerger becoming effective, each Tiziana Shareholder (including the initial subscriber in Accustem) will hold one Accustem Share for each Tiziana Share held at the Demerger Record Time.It is intended that holders of warrants and options over Tiziana Shares will be granted equivalent instruments in respect of Accustem Shares as a part of the Demerger.It is intended that Accustem will seek admission to the standard segment of the Official List and admission to trading on the London Stock Exchange plc by way of an IPO in late Q4 2020 ("Accustem Admission") and potentially a dual listing on NASDAQ in 2021.Whilst the Accustem Shares will be allotted on the completion of the Demerger, it is unlikely that the process to obtain a standard listing on the Official List and admission to trading on the London Stock Exchange will be complete by the date of completion of the Demerger. 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